RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
mir-29a
RNA ID
RNA Type
miRNA
Alteration Pattern
histone deacetylase
Species
mus musculus
Detection Methods
RT-PCR; immunofluorescence; etc.
Target
NA
Pathway
NA
PubMed ID
Title
Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4
Year
2015
Function
Post translational modification of creb-1 inhibited the profibrotic effects of tgf b1 in hscs via smad dependent and independent signaling pathways.
RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
mir-29a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
PCR; dual-lucimmunofluorescenceerase reporter assay etc.
Target
HDAC4; TGF-B; SMAD3
Pathway
HDAC4-5; TGF-BETA SIGNALING PATHWAY; SMAD4 SIGNALING PATHWAY
PubMed ID
Title
Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4
Year
2015
Function
The activation of mir-29a regulates the activation of hepatic stellate cell phenotype by inhibiting histone deacetylase.